The black spots represent Black Lotus spawns, and the bright green arrows are the teleporters. You can also find many Wooden Chests, Mist Wood, Deep Mushrooms along the pathways, as well as Ore and Cattails in the center cave area, but those items haven't been marked on this map.
The Route that I use is basically this:
1) Enter the Cave of Solitude via Shosun Village and keep to the left side of the road, following the curve around, past all the spiders, past Mossback and the Corrupted Earth Spirits and head back to the third hut you'll see. Keep bearing left and look behind the wagon near the 4th hut.
2) Second spawn site is on the other side of that hut, then follow the path up to the third hut again, where the Green Teleporter is located. There is a spawn near the teleporter.
3) Continue along the path to the opposite end of this section, where there are two more spawns near the far hut. Then return along the other side of the road, where another spawn is located kitty-corner from the hut. Use the Green Teleporter to go to the Hub.
4) Collect Ore, etc., here if you need it and have time.
5) Use the Blue Teleporter to the area with the Imitsu Retainers and check for spawns nearby and across the road. Head up the road on your right to Koto's hut. There are two spawns outside that hut.
6) Follow the path away from Koto's hut on the right side, turning to the right at the corner. There are two spawns at the curve where the Tainted Forest Imps begin, one on the far side of the road near the haystack and another at the very point of this turn. If you are daring enough to continue past the Imps, there is another two spawns up near Binh Hoa the sheep. If not, return to the Blue Teleporter and the Hub.
7) From the Hub, take the Yellow Teleporter to Kanago's Dojo, where there are two spawns near his hut. This is the end of the line, change realms and go round again.
Once you are harvesting the Cave of Solitude, you may want to place a mark either near Kanago's Dojo or Binh Hoa and use those as your end points, using the Green Teleporter between the Blue and Yellow, since the Green Teleporter area is basically a big circle and you can then return to the Hub.
Good Luck and Happy Harvesting!
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